CMSB 2021 solicits original research articles, tool papers, posters, and highlight talks on the modelling and analysis of biological systems and networks as well as the analysis of biological data. The conference brings together researchers from across biological, mathematical, computational, and physical sciences who are interested in the modelling, simulation, analysis, inference, design, and control of biological systems. It covers the broad field of computational methods and tools in systems and synthetic biology and their applications.

Topics of interest include, but are not limited to:

  • formalisms for modelling biological processes
  • methods and tools for biological system analysis, modelling and simulation
  • frameworks for model verification, validation, analysis, and simulation of biological systems
  • high-performance methods for computational systems biology
  • identification of biological systems
  • applications of machine learning
  • network modelling, analysis, inference
  • automated parameter and model synthesis
  • model integration and biological databases
  • multi-scale modelling and analysis methods
  • design, analysis, and verification methods for synthetic biology
  • methods for biomolecular computing and engineered molecular devices
  • data-based approaches for systems and synthetic biology
  • optimality and control of biological systems
  • modelling, analysis and control of microbial communities

The conference welcomes new theoretical results with potential applications to systems and synthetic biology, as well as novel applications and case studies of existing methods, tools, or frameworks.

The CMSB 2021 proceedings will be published in the Springer LNCS/LNBI series and indexed by ISI Web of Science, Scopus, ACM Digital Library, DBLP, and Google Scholar.

A selection of best papers will be invited to be extended and submitted to a special issue of BMC Bioinformatics at a discounted Author Processing Charge (1 282 GBP).


  • Regular and tool papers:
    • submission open: March 15, 2021
    • submission deadline: April 12, 2021 April 30, 2021 (new submissions will be closed at April 30 AoE, updates will be allowed until May 5 AoE).
    • notification: June 11, 2021
    • final version: July 5, 2021
  • Highlight talks (presentation only):
    • extended abstract submission: May 31, 2021
    • notification: June 11, 2021
  • Posters:
    • extended abstract submission: June 18, 2021
    • notification: June 25, 2021

All of the deadlines are AoE (Anywhere on Earth):


Contributions should be submitted to one of the following categories:

A) REGULAR PAPERS: Regular papers should describe original work that has not been previously published and is not under review for publication elsewhere. Accepted regular papers will be published as part of the conference proceedings in the Springer LNCS series. Papers in this category should not exceed 15 pages in the Springer LNCS style (including main figures and tables, excluding references and appendix).

B) TOOL PAPERS: Tool papers should present new tools or public websites, new tool components or novel extensions to existing tools or websites supporting biological system modelling, analysis, simulation, or similar. Submissions must include information on methods, tool availability, and selected application results. They should be original and not previously published in a similar form. Accepted tool papers will be published as part of the conference proceedings in the Springer LNCS series. Papers in this category should not exceed 6 pages in the Springer LNCS style (including main figures and tables, excluding references and appendix).

For the tool evaluation, authors shall either submit an artifact along with the paper by the submission deadline via Easychair, or provide clear indications in the paper on how to locate it on the web (mainly in case the artifact size exceeds Easychair size limit of approx. 100MB). Upon acceptance, a permanent link to the artifact in a public repository (such as zenodo) should be attached to the final version of the paper. If none of this is applicable, authors shall contact the program chairs before submission deadline to agree on alternative means of evaluation. Tool papers will undergo a dedicated reviewing process that includes the testing of the tools, with specific feedback returned to the authors. Authors of accepted tool papers will be encouraged to showcase their tool in a tool session at the conference.

C) POSTERS: Extended abstracts should be submitted to propose poster presentation of original unpublished work, or of major results published or accepted in the last year in a high-quality journal or conference. The abstracts should be submitted in Springer LNCS style and should not exceed 4 pages all included. Authors of accepted abstracts will be invited for presentation in a poster sessions and/or for flash presentations.

D) HIGHLIGHT TALKS: Highlight talk proposals should be submitted in the form of an extended abstract, for possible oral presentation without publication of related material in the conference proceedings. We particularly welcome submission of recently published work. Submitted abstracts summarizing the results and their relevance should not exceed 2 pages including references.


All submitted papers and extended abstracts have to be written in English and must be submitted in the form of a PDF file using the EasyChair online submission system, at the following link:

Instruction for the Springer LNCS style:

Each submission will be reviewed by at least three members of the Program Committee (see above for specific reviewing information about tools). All accepted contributions must be presented at the conference by one of the authors.